Библиотеки химических соединений для ин витро скрининга (HTS)

Научно-исследовательский институт ХимРар предлагает услуги по ин силико и ин витро высокопроизводительному скринингу (high-throughput screening, HTS) биологической активности индивидуальных соединений и библиотек разнообразных химических соединений.

В наличии коллекция в 1.6 миллиона соединений (diverse collection):

• Discovery chemistry public available >4Y old (DC) – 1,000,000
• New chemistry public available 3 Y old (NC) – 485,000 соединений
• Innovative chemistry non-exclusive 1Y old (IC ) – 120,000 соединений

Список доступных для ин витро скрининга библиотек соединений

Новые библиотеки (2020):

• 3D-Pharmacophore Based Diversity Library -52,000 соединений
• Opportunistic Pathogens of Immunocompromised Hosts Annotated Library – 2,100 соединений
• RNA-Protein Interaction Inhibitors Library – 2,111 соединений
• Cysteine Targeted Covalent Library – 41,378 соединений
• 300k Representative Соединений Library (Bemis-Murcko Algorithm) – 300,000 соединений
• Antiviral Annotated Library – 22,775 соединений
• PLpro Library – 6,442 соединений
• 3CLpro Library – 4,871 соединений
• ACE2 Library – 3,117 соединений
• MCL1 Targeted Library Selection – 12,000 соединений
• Arginase Targeted Library – 2,000 соединений
• Chelators targeting matrix metalloproteinases library – 9,300 соединений
• Ion Channels Focused Library – 26,000 соединений
• Histone Deacetylases (HDAC) Targeted Library Selection – 9,500
• CNS Annotated Library – 733 соединений
• PTPN-targeted-library Library – 33,000 соединений
• CORONAVIRUS Library – 21,145 соединений
• Lipid Metabolism Library – 9,000 соединений
• Human Phosphatases Annotated Library – 225 соединений
• Human Receptors Annotated Library – 5,600 соединений
• Purine Based Nucleoside Library – 1,300 соединений
• STING Agonist Library – 6,000 соединений
• Nucleoside Mimetics Library – 2,600 соединений
• RPTP Targeted Library – 3,900 соединений
• Human Transcription Factors Annotated Library – 5,278 соединений
• Human Proteases Annotated Library – 3,000 соединений
• Human Kinases Annotated Library – 2,500 соединений
• Human Ion Channels Annotated Library – 400 соединений
• Human GPCR Annotated Library – 5,800 соединений
• Regenerative Medicine Focused Library – 23,000 соединений
• Selective Target Activity Profiling library – 18,000 соединений
• Neurotransmitter Transporter Inhibitors library – 12,000 соединений
• MCE-18 Trends in Medicinal Chemistry – 50,000 соединений
• Epitranscriptome Focused Small Molecule Library – 21,000 соединений
• Cardiovascular Library – 23,000 соединений
• RNA Isosteric Trinucleotide Mimetics Library – 29,000 соединений
• Protein Kinases Inhibitors Library – 38,000 соединений
• Antibacterial соединений library – 15,000 соединений
• Therapeutical Diversity Annotated Library – 2,000 соединений &  6,500 соединений
• Covalent inhibitors Library – 12,000 соединений

Аннотированные библиотеки:

• Antiviral Annotated Library – 22,775 соединений
• CNS Targets Activity Set – 7,000 соединений
• Therapeutical Diversity Annotated Library – 2,000 соединений & 6,500
• 3D-Biodiversity Library – 34,000 соединений
• Target Identification, Phenotypic Screening Library (TIPS) – 35,000
• Launched & Clinically Evaluated Drugs Library – 274 соединений
• ChemoGenomic Annotated library for Phenotypic Screening – 99,000
• Selective Target Activity Profiling library – 18,000 соединений
• Human GPCR Annotated Library – 5,800 соединений
• Human Ion Channels Annotated Library – 400 соединений
• Human Kinases Annotated Library – 2,500 соединений
• Human Proteases Annotated Library – 3,000 соединений
• Human Transcription Factors Annotated Library – 5,300 соединений
• Human Receptors Annotated Library – 5,600 соединений
• Human Phosphatases Annotated Library – 225 соединений
• CNS Annotated Library – 773 соединений
• Opportunistic Pathogens of Immunocopromised Hosts Annotated Library – 2,100 соединений

Разнообразные библиотеки (Diversity libraries):

• 3D-Pharmacophore Based Diversity Library -52,000 соединений
• 3D-Diversity Natural-Product-Like Library -21,000 соединений
• Representative Diversity libraries out of 1,6M stock – 50,000 соединений, 100,000 соединений, 150,000 соединений
• 300k Representative Соединений Library (Bemis-Murcko Algorithm) – 300,000 соединений
• SmartTM Library – 54,000 соединений
• Soluble Diversity Library – 9,500 соединений
• MEC-18 Trends in Medicinal Chemistry – 50,000 соединений
• Targeted Diversity Library – 45,429 соединений

Фокусированные библиотеки:

• PPI CDI Library – 230,000 соединений
• PPI Helix Turn 3D-Mimetics Library – 74,000 соединений
• PPI Tripeptide Mimetics Library – 25,000 соединений
• Peptidomimetic Library – 38,400 соединений
• PDZ PPI Library – 4,000 соединений
• Nonpeptide Peptidomimetics PPI library – 22,000 соединений
• Eccentric PPI Library – 13,000 соединений
• Cyclic Ugi PPI Library – 10,000 соединений
• Alpha-Helix Mimetics Library– 28,000 Соединений
• Peptidomimetics of Beta-Turn Motifs Library – 2,679 соединений
• Macrocycles Library – 3,300 соединений
• 3D Mimetics PPI Library – 2,000 соединений
• Recognition Elements PPI Library – 26,000 соединений
• Bcl2-PPI Inhibitors Library – 11,000 соединений
• Library of Small Molecule Inhibitors of beta-Catenin Signaling – 8,000
• MDM2-p53 interaction inhibitors Library – 23,000 соединений
• SH2 Library – 12,000 соединений
• Library of Small Molecule Modulators & Inhibitors of Bromodomains – 5,816 соединений
• DGK Inhibitors Library – 12,000 соединений
• Focused Epigenetics Set – 30,431 соединений
• Hsp90-Targeted Library – 13,000 соединений
• SH2 PTB Focused Library – 7,000 соединений
• Nucleoside Mimetics Library – 2,600
• Purine Based Nucleoside Library – 1,300 соединений
• CNS MPO Library – 30,000 соединений
• CNS Targets Library – 44,000 соединений
• CNS targets activity set – 7,000 соединений
• CNS Library – 26,000 соединений
• CNS BBB Library – 23,000 соединений
• CNS Annotated Library – 773 соединений
• GABA library – 17,915 соединений
• Purinergic Library – 3,500 соединений
• Neurotransmitter Transporter Inhibitors library – 12,000 соединений
• Ion Channels Focused Library – 26,000 соединений
• Ligand-Gated Ion Channels Library – 4,000 соединений
• Voltage-Gated Ion Channel-Targeted Library – 5,000 соединений
• GPCR Target Platform Library – 40,000 соединений
• PTPN-targeted-library Library – 33,000 соединений
• Protein Kinases Inhibitors Library – 38,000 соединений
• Akt-Targeted Library – 12,000 соединений
• Allosteric Kinases Inhibitors Library – 26,000 соединений
• Aurora A-B Kinases Library – 10,000 соединений
• KRAS-Targeted Library – 11,000 соединений
• Proline Kinase Library – 2,000 соединений
• Type II Kinase Inhibitors Library – 8,000 соединений
• C-Met Library – 16,000 соединений
• PI3K-Targeted Library – 19,000 соединений
• Antiviral Annotated Library – 22,775 соединений
• PLpro Library – 6,442 соединений
• ACE2 Library – 222 compound
• 3CLpro Library – 4,871 соединений
• Antiviral Library – 87,043 соединений
• Anti-HIV1 Library – 21,000 соединений
• Antiviral HBV – 11,000 соединений
• CORONAVIRUS Library – 21,145 соединений
• Androgen Receptor Antagonists Library – 4,300 соединений
• RAR (Nuclear receptors) Ligands Library – 6,000 соединений
• Anticancer Library – 65,000 соединений
• Antimitotic Tubulin Library – 18,000 соединений
• Histone Deacetylases (HDAC) Targeted Library Selection – 9,500
• Developmental Pathway (Hh/Wnt) Set – 2,000 соединений
• MEF2-HDAC (class II) Modulators Library – 6,000 соединений
• Arginase Targeted Library – 2,000 соединений
• Chelators targeting matrix metalloproteinases library – 9,300 соединений
• MCL1 Targeted Library Selection – 12,000 соединений
• Cysteine Proteases Inhibitors Library – 8,000 соединений
• Serine Proteases Inhibitors Library – 37,000 соединений
• PRMT Library – 31,000 соединений
• Immunological Library – 7,300 соединений
• PD-1/L1 Library – 500 соединений
• TLR-8 ligands Library – 900 соединений
• Anti-Inflammatory Library – 28,000 соединений
• Cardiovascular Library – 23,000 соединений
• Lipid Metabolism Library – 9,000 соединений
• Anti-Aging Library – 50,000 Соединений
• Regenerative Medicine Focused Library – 23,000 соединений
• Autophagy-Targeted Library – 17,000 соединений
• RNA Isosteric Trinucleotide Mimetics Library – 29,000 соединений
• Chemokines Library – 20,000 соединений
• Angiogenesis library – 17,000 соединений
• BRD4 targeted library – 5,000 соединений
• Integrin Receptors Targeted library – 2,000 соединений
• Indoleamine 2,3-dioxygenase 1 focused library – 6,000 соединений
• Neuropeptide S Library – 3,000 соединений
• RNA-Protein Interaction Inhibitors Library – 2,111 соединений
• Nucleic acid ligands – 9,000 соединений
• RAR (Nuclear receptors) Ligands Library – 6,000 соединений
• Epitranscriptome Focused Small Molecule Library – 21,000 соединений
• RPTP Targeted Library – 3,900 соединений
• Adenosine Receptors Targeted Library – 21,000 соединений
• Glucocorticoid receptors Library – 5,000 соединений
• Macl-GPIb alpha Interaction Library – 27,000 соединений
• STING Agonist Library – 6,000
• Antiparasite library – 28,000 соединений
• Anti-infective Library – 20,600 соединений
• Antibacterial соединений library – 15,000 соединений
• Covalent inhibitors Library – 12,000 соединений
• Cysteine Targeted Covalent Library – 41,378 соединений
• New Agro Library – 50,000 соединений
• Antifungal Library – 18,000 соединений
• Beyond the Flatland Library sp3 enriched – 100,000 соединений
• Spiro-library – 19,000 соединений
• Indole Derivatives – 12,000 соединений
• 3D-Diversity Natural-Product-Like Library – 21,000 соединений
• Natural-Product-Based Library – 4,000 соединений
• Natural Соединений Library – 374 соединений
• Steroid-like-соединений – 543 соединений
• 3D-Fragment-Library – 4,500 соединений
• Fragments Library – 13,000 соединений
• Dark Chemical Matter Library – 25,000 Соединений
• Frequent Hitters Library – 9,000 соединений

Список библиотек регулярно обновляется.

Для получения актуальной информации по наличию и условиях продажи библиотек и/или услуг по ин силико и ин витро скринингу вы можете отправить запрос на email указанный ниже.